Agglomeration Behaviour and Modification of Spherical Crystallization Process of Pharmaceuticals by the Emulsion-Solvent-Diffusion Method and Proposed Closed-Circuit Batch System
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Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method
Objective(s):The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. Quasi-emulsion solvent diffusion was used as a crystal modification method. Materials and Methods: Corn starch was dissolved in hydrochloric acid at 80˚C and then ethanol as a non-solvent was added with lowering temperature ...
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felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to bcs class ii category. hence, its low water solubility limits the pharmacological effect. the aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...
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Felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to BCS class II category. Hence, its low water solubility limits the pharmacological effect. The aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...
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15 صفحه اولAgglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer.
Purpose: The quasi-emulsion solvent diffusion (QESD) has evolved into an effective technique to manufacture agglomerates of API crystals. Although, the proposed technique showed benefits, such as cost effectiveness, that is considerably sensitive to the choice of a stabilizer, which agonizes from a absence of systemic understanding in this field. In the present study, the combination of differe...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1991
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.111.8_451